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Research & Clinical Evidence

Human Trials and Scientific Studies Behind Key Ingredients

At NEE-V, our formulation is informed by scientific research on bioactive collagen peptides and supporting nutrients. Below is a summary of peer-reviewed human trials and clinical studies relevant to VERISOL® collagen peptides, vitamin C, biotin and silica, highlighting evidence related to skin health parameters such as elasticity, hydration and wrinkles.

Verisol® Bioactive Collagen Peptides

Several randomized, double-blind, placebo-controlled human clinical trials have investigated oral supplementation with specific bioactive collagen peptides — including VERISOL® — demonstrating measurable changes in skin health outcomes.

  • Reduced wrinkle volume and dermal matrix synthesis: Oral intake of VERISOL® collagen peptides significantly reduced eye wrinkle volume and increased dermal matrix components (procollagen type I and elastin) in healthy adults compared with placebo in a double-blind clinical trial. PubMed

  • Improved elasticity and hydration: Another study found that daily supplementation with 2.5 g of VERISOL® over 8 weeks significantly improved skin elasticity and hydration, with results more pronounced at 8 weeks. MDPI

  • Positive hydration and elasticity effects: Additional clinical evidence supports that VERISOL® collagen supplementation can enhance skin hydration and elasticity while reducing wrinkles over 4–8 weeks of consistent intake. nutraceuticalsworld.com

VERISOL® has been the subject of multiple published studies showing beneficial effects on parameters commonly associated with skin ageing and connective tissue support. nutritionaloutlook.com

Broader Evidence for Collagen Peptides

Beyond product-specific trials, meta-analyses and systematic reviews of hydrolysed collagen supplementation indicate consistent trends:

  • Improved skin elasticity and hydration: A meta-analysis of randomized controlled trials concluded that oral hydrolysed collagen supplementation can reduce wrinkles and improve skin elasticity and hydration compared with placebo. PubMed

  • Dermal structure support: Clinical research reviews report that collagen peptides are absorbed intact into the bloodstream and can accumulate in skin tissue, where they may stimulate collagen synthesis and support dermal extracellular matrix structure. PMC

Biotin and Silica in Skin Health

While the evidence base for vitamin C in supporting normal collagen formation is well established in nutrition science, targeted human clinical trials specifically isolating biotin or silica effects on skin structure are more limited. However, nutrient-focused research and broader clinical findings suggest that:

  • Vitamin C contributes to normal collagen formation in skin and connective tissues as part of nutrient metabolism.

  • Nutrients such as biotin and silica are commonly used in cosmetic and wellness supplements based on their roles in connective tissue health and hair/nail support (though human clinical trials specifically isolating effects on skin for these alone are less robust than for collagen peptides).

How This Research Relates to NEE-V

The human clinical evidence for VERISOL® and hydrolysed collagen peptides suggests that consistent daily intake of specific bioactive collagen peptides — such as those included in NEE-V — may contribute to:

  • improvements in skin elasticity

  • enhanced skin hydration

  • reduction in wrinkle appearance

  • maintenance of connective tissue integrity

These findings come from randomized, placebo-controlled human trials using well-defined collagen peptide formulations and measured outcomes over weeks of supplementation. PubMed+2MDPI+2

Notes on Scientific Context

  • Study populations: Many collagen trials involve healthy adult women aged 30–65 years.

  • Typical dosages used in research: Daily amounts in clinical studies often range from ~2.5 g to ~10 g of specific collagen peptides.

  • Outcome measures: Objective skin parameters such as elasticity, hydration and wrinkle volume are assessed with validated dermatological instruments.

    Human Clinical Research & Peer-Reviewed References

    VERISOL® / Bioactive Collagen Peptides (Human Trials)

    These are the strongest, most defensible references for collagen.

    1. Proksch et al. (2014)
    Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis
    Skin Pharmacology and Physiology, 27(3), 113–119
    🔗 https://pubmed.ncbi.nlm.nih.gov/24401291/
    🔗 https://doi.org/10.1159/000355523

    ✔ Randomised, double-blind, placebo-controlled human trial
    ✔ Used 2.5 g specific collagen peptides
    ✔ Measured wrinkles and dermal matrix synthesis

    2. Proksch et al. (2014)
    Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology
    Skin Pharmacology and Physiology
    🔗 https://pubmed.ncbi.nlm.nih.gov/23949208/

    ✔ Human clinical trial
    ✔ Skin elasticity, hydration and wrinkle parameters

    3. Choi et al. (2014)
    Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study
    Journal of Cosmetic and Laser Therapy, 16(3), 132–137
    🔗 https://pubmed.ncbi.nlm.nih.gov/24131124/
    🔗 https://doi.org/10.3109/14764172.2013.854115

    ✔ Randomised controlled human study
    ✔ Objective skin measurements

    4. de Miranda et al. (2021) – Systematic Review
    Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis
    International Journal of Dermatology
    🔗 https://pubmed.ncbi.nlm.nih.gov/33742704/

    ✔ Meta-analysis of human RCTs
    ✔ Confirms trends in elasticity, hydration and wrinkles

    Vitamin C (Ascorbic Acid) – Human Evidence

    Vitamin C’s role is structural and biochemical, not cosmetic hype.

    5. Pullar et al. (2017)
    The roles of vitamin C in skin health
    Nutrients
    🔗 https://pubmed.ncbi.nlm.nih.gov/28805671/
    🔗 https://doi.org/10.3390/nu9080866

    ✔ Explains vitamin C’s role in normal collagen formation
    ✔ Widely accepted nutritional science

    Biotin (Human Evidence – Contextual, Not Overclaimed)

    Biotin evidence is stronger for deficiency states, which is how it should be framed.

    6. Patel et al. (2017)
    Biotin deficiency: a rare cause of hair and nail changes
    Skin Appendage Disorders
    🔗 https://pubmed.ncbi.nlm.nih.gov/28879195/

    ✔ Human clinical relevance
    ✔ Supports inclusion without exaggerated claims

    Silica (Human & Nutritional Research)

    Human trials are limited, but nutritional support evidence exists.

    7. Jugdaohsingh (2007)
    Silicon and bone health
    Journal of Nutrition, Health & Aging
    🔗 https://pubmed.ncbi.nlm.nih.gov/17691335/

    ✔ Human nutritional relevance
    ✔ Supports connective tissue role (not cosmetic claims)